First of all - does the user have have full access permissions to the other Exchange accounts? If not, correct this as per this TechNet article: Manage Full Access Permissions: Exchange 2010 Help and try again. Should this not help/apply, consider setting the Auto Replies via OWA, separately for each account; or using a 3rd party Exchange add-on which can be installed on any machine in the domain, like CodeTwo Out of Office Manager: www.codetwo.com/out-of-office-manager