Run the exe and install to a temp directory (e.g. C:\Datapickerfix). It will extract the two files that are updated in the SIMS client directory so you can use that for a rollout via AD. As has been stated already, you can't apply this when running SIMS or any third party apps that use the particular dll (schoolcomms, et cetera). Subsequently, I'd apply it as a startup or logon script.
FYI - for those who use Centrastage - You can use PV.exe to periodically check if pulsar is running, then apply the fix when it's closed.