I've been banging my head against a weird Smart Notebook problem for a couple of weeks now, and having just solved it, wanted to share my findings in case it proved useful to anyone.
The problem was that when loading up Smart Notebook, we were getting the following error message:
"Smart Notebook software was unable to load the Microsoft .NET Framework 4 client profile", with prompts to reinstall .NET 4. Reinstalling .NET, for the record, made no difference.
It was only doing it for one user, and despite not having roaming profiles in place, was affecting said user on multiple computers, even after having reimaged one.
After a lot of trawling about on the web, and doing side-by-side comparisons of user profiles on the same laptop that DIDN'T have the problem, I found that the custom.xml file in My Documents\SMART Notebook was showing as 0Kb for the affected user, but 5Kb for any other user not having the problem.
Replacing the 0Kb file with the 5Kb file fixed the issue, with Smart Notebook now loading up fine.
The reason it'd been affecting the user was that their files are held centrally with folder redirection in place.
Apologies if this doesn't come as news to most people, but it took me ages to find the solution, so I'd thought I'd be nice and share