Ensure you're logged in with local administration rights and permissions and have current updates recommended by Microsoft Update installed. You will want to also have Microsoft .NET Framework 4 Client and Visual C++ 2008 and 2010 installed. Also confirm in System Configuration (msconfig.exe) you have normal bootup rather than selective or diagnostic bootup selected.
Then try manualling uninstalling all the SMART software listed in Start > Control Panel > Programs and Features. The run Education Software 2011 to reinstall SMART Notebook, SMART Product Drivers and Common Files: visit smarttech.com and select Support > Downloads > "10.8 for Windows" under SMART Notebook. If the issue persists, contact SMART Support directly by phone or web form.