First time poster here and this thread alone made it seem like a good idea to register.
We are also having the problem with our Windows 2012 R2 Servers. I have servers running Windows 2012(not R2) and have not seen the problem recently but was most definitely having the issue months ago. The R2 Servers I just stood up are having the issue pretty much daily.
We are running a full virtual infrastructure. ESXI 5+ on a mix of hardware. Dell servers, HP servers, extreme networks switches, you name it, we have it someplace. I feel we can all pretty much agree this is an issue on the software end of things.
As a work around, I am letting KACE restart the "Server" service every 30 minutes to prevent any down time. That still creates about 15-20 seconds of offline sharing though and is really not an acceptable option.
Looking through the logs, I do not see anything going down and the "Server" service has always been running when my shares were not accessible. I can't say I have seen this problem on shares that are not also hosting printers. That said, I have no technical data to back that up. Just what I noticed. I read some info about disabling the IIS roles. I don't have any of that installed on my file servers so that can't be it.