We have 1100+ MR24/26 with more on the way, and a handful of MR66. I believe we had 11 RMAs over last 18 months, all bricked in some fashion--most of these were failed firmware upgrades, that could not be recovered by factory reset, and a handful of just outright dead (no LEDs).
Our issues are mostly with iOS devices: to get various iPads to play ball we had to tune down radios to eliminate any overlap, and had to manually channel 2.4Ghz radios at each site (1,6,11). AP overlap and auto-selection simply did not work for iPads, most would connect to one AP and stick to it for dear life even if a closer AP was readily available. Other than that, biggest issue is having enough APs to avoid deadzones in rooms that have high interference construction.
We did see connectivity issues/drops with OS 10.7/8 but we only have a handful of those, so it did not get much attention.