I have SIMS working on a 2016 VM ware VM (part of a farm), has RDSH and Licencing, SIMS runs as a RemoteApp program. Didn't do anything special for the install, just added the server to SOLUS3. Uses traditional profiles in the Users folder.
This is with a 2012r2 Physical with Connection broker, RDSH, RD Virtualisation host, licencing and RD Web access. No apps on this one, just Hyper-V VM running a client OS.