We're in the process of running the SUU on the affected servers now, will let you know how it goes for us. I've found rebooting the server seems to alleviate the issue for a short period so we've managed to avoid any end user issues by rebooting when needed.
All affected servers have been updated up to the April cumulative update (kb5501347), but it doesn't seem to correlate with when the issues occurred, some servers had this installed for several weeks before any faults started happening, and one server seemed to be having this issue before this update was applied looking into event viewer, so sort of suggests it wasn't this update at fault... we've started deploying the may cumulative to see if this has a fix on it but not hopeful
Also we've had this issue on a couple of server 2019 boxes too so doesn't seem to be 2016 specific. Hopefully the bios & firmware updates will work, we are a few versions behind by the looks.