As the other two have suggested. I would also recommend deploying 'User Profile Hive Cleanup Service'. Doing so saves you from having to perform a restart, you will still have to be logged in as another user.
http://www.microsoft.com/downloads/details.aspx?FamilyID=1B286E6D-8912-4E18-B570-42470E2F3582&displaylang=en