We are an IT service provider and we had several clients with this profile issue this past Monday morning. Rebooting the server (DC) fixed the problem. We continue to have the same intermittent log on issues for three days now. All of the environments are different, some are on terminal service, some are logging in to a domain. Different antivirus products. I am thinking that it must be a Microsoft thing. Possibly related to a patch that was recently pushed out. Anyone have any news on this?