Hi
I'm actually a teacher but I work closely with our Data Manager. Hope it's ok for me to post here!
2100 pupil, 11-18 school. KS3/4/5
MIS: SIMS with SLG for parents and some staff (all were offered it but a lot never took it up)
Analysis for KS3/4: SISRA (mainly for SLT). For teachers, used to use Excel, but this year started developing our own system, MAP Learners. (www.maplearners.co.uk) Middle leaders are much preferring it over SISRA or the old Excel sheets we used. The data exports from SIMS are very quick too - we didn't need to set up more than one or two marksheets.
Target setting: Basically 4 levels of progress from KS2, adjusted up if necessary at end of KS3.
KS5: ALPS