User Profile Service service failed the sign-on. User profile cannot be loaded.

[microbrew22]

Error when logging in: User Profile Service service failed the sign-on. User profile cannot be loaded.

 

This is a random error we keep getting again and again in our Windows 10 lab. Clicking ok and try again will allow login.

Note: We are running mandatory roaming profiles.

 

Windows cannot copy file \\?\C:\Users\Win10lab\AppData\Local\Microsoft\Windows\INetCache\Low\Content.IE5\ to location \\?\UNC\Server1\Profiles\Win10lab.2016.V5\AppData\Local\Microsoft\Windows\INetCache\Low\Content.IE5\. This error may be caused by network problems or insufficient security rights.

 

DETAIL - Access is denied.

 

Any thoughts how to address this?