[1607, au] Corrupted profiles?

[Sir]

Not sure about this as I have reports this morning of more issues with staff laptops. I have had issues with desktops since last Thursday of lost outlook profiles and taskbar shortcuts all disappearing and redirected desktop program shortcuts unavailable.... some not all and it points to issues with redirected appdata... more and more are being reported and I am wondering if anyone else is seeing this.... also was an issue on one of my win7 machines on Friday... now had three members of staff just email saying they cannot save docs while on the train on the way to work saying all docs are loading in comparability mode.... is a rogue update breaking things for me?! I need to be at another school so any tips I can send to a tech there would be greatly appreciated here! Happy dark and early Tuesday morning