Definitely. Most printers have an "ignore A4/Letter mismatch" setting somewhere (often buried deep in other menus but if you hunt it down you will find it ...)
Originally Posted by pallen
As others have said, get *all* the regional settings right when you first install a machine - it really helps later!
If you really want to clean out printer drivers it's worth looking at this Kyocera driver deleter which deletes all known printer drivers cleanly.
There was a fantastic bug in an early version of Word where if you pasted any text into a document it would reset the page size to letter ...