We've a problem with a laptop that is taken off site,
User logs in at home using the cached account, and the internet settings (via gpo) are still enforced - so IE fails for them at home.
On further investigation it seems It's getting a 1530 error in the event log which points to internet settings. This appears to be leaving the GPO settings for the local account

Code:
Warning	19/01/2012 13:10:25	User Profile Service	1530	None


Windows detected your registry file is still in use by other applications or services. The file will be unloaded now. The applications or services that hold your registry file may not function properly afterwards.  

 DETAIL - 
 2 user registry handles leaked from \Registry\User\S-1-5-21-448539723-796845957-839522115-9358:
Process 124 (\Device\HarddiskVolume2\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-448539723-796845957-839522115-9358\Software\Microsoft\Windows\CurrentVersion\Internet Settings
Process 124 (\Device\HarddiskVolume2\Windows\System32\svchost.exe) has opened key \REGISTRY\USER\S-1-5-21-448539723-796845957-839522115-9358\Software\Policies\Microsoft\Windows\CurrentVersion\Internet Settings
any clues?