I use VEEAM to do a nightly backup of all our servers, our MIS and Bio servers are done twice a day, all to a NAS in another physical building. I do a fortnightly backup into a fire safe and a weekly back up to a separate NAS located in a 3rd building.

I am looking to hold an offsite backup at one of the primaries we support as well in the near future.

With us, Im hoping its more a case of differences in age of backups, then loosing the backups. All out NAS's have ISCSI - so we could run the VMs straight off there, but likely hood is I would shift them to a new server. Our current setup is a failover cluster with a SAN, so one would hope only a major instance would bring it down...